RNAnalytics

RNAnalytics specializes in developing innovative analytical methods for the characterization of Lipid Nanoparticles (LNPs) used in RNA therapy. 

This includes the development of new methods for analyzing LNPs and RNA encapsulation efficiency, such as particle size and size distribution analysis using Capillary Electrophoresis and Taylor Dispersion Analysis.


Through these research activities, RNAnalytics aims to establish unique methods for analyzing LNP-based RNA therapeutics, setting the company apart from others in the field.


Research & Development

RNAnalytics sets new standards in the efficient characterization of LNPs with the GeneVecto Analyzer. This one-step analysis method combines TDA and CE to accurately measure particle size, size distribution, and RNA encapsulation efficiency. The GeneVecto Analyzer simplifies complex analytical processes, reduces costs, and increases reproducibility, making it a user-friendly solution for research and development.


Quality Control & Stability
Since LNPs can become unstable due to physical and chemical influences such as pH, temperature, humidity, light, and oxidation, it is crucial to develop methods that optimize stability and shelf life. RNAnalytics is actively working on procedures to enhance stability and prevent particle aggregation, ensuring the therapeutic efficacy and safety of LNPs.

Purity & Contaminations
Impurities in LNPs can affect biological activity and compromise the safety of mRNA therapeutics. RNAnalytics is developing highly precise methods for identifying and removing impurities to meet the highest quality standards for ensuring the safety and efficacy of therapeutics.

Scalability and Production Methods
The development of scalable production methods for LNPs is essential for their clinical application. RNAnalytics is creating analytical methods that support process development and enable the consistent production of LNPs on a larger scale. These methods ensure high batch consistency and precise control over particle size and size distribution.


Future Outlook

To further improve LNP analysis, RNAnalytics will expand its methodology to include HPLC and mass spectrometry, allowing for more detailed analysis of LNP structures and compositions. Additionally, cell-based assays are being developed to assess the potency and tissue specificity of LNPs, which are critical for the clinical application of mRNA therapeutics.

 

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